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The U.S. Supreme Court on Tuesday denied a stay of execution appeal from Teresa Lewis, scheduled to be the first woman executed in the United States in five years.

Virginia Gov. Bob McDonnell previously rejected a clemency request from the death row inmate, who is set to die by injection Thursday evening.

Lewis, a 41-year-old grandmother, pleaded guilty to her part in the 2002 slayings of her husband and stepson in their rural home near Danville, Virginia, about 145 miles from Richmond. Two male co-conspirators — the triggermen — were given life in prison without parole.

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