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Israel shelled the United Nations headquarters in the Gaza Strip on Thursday, engulfing the compound and a warehouse in fire and destroying thousands of pounds of food and humanitarian supplies intended for Palestinian refugees.

U.N. workers and Palestinian firefighters, some wearing bulletproof jackets, struggled to douse the flames and pull bags of food aid from the debris after the Israeli attack, which was another blow to efforts to ease the humanitarian crisis in the Gaza Strip. Dense smoke billowed from the compound.

U.N. Secretary-General Ban Ki-moon, who is in the region to end the devastating offensive against Gaza’s Hamas rulers, demanded a “full explanation” and said the Israeli defense minister told him there had been a “grave mistake.”

Israeli Prime Minister Ehud Olmert said the military fired artillery shells at the U.N. compound after Hamas militants opened fire from the location. Three people were wounded.

“It is absolutely true that we were attacked from that place, but the consequences are very sad and we apologize for it,” he said. “I don’t think it should have happened and I’m very sorry.”

A senior Israeli military officer had also said Israeli troops shelled the compound after coming under fire from Palestinian militants there — an account dismissed by a U.N. official there at the time as “nonsense.”

Even as a top Israeli envoy went to Egypt to discuss a cease-fire proposal, the military pushed farther into Gaza in an apparent effort to step up pressure on Hamas. Ground forces thrust deep into a crowded neighborhood for the first time, sending terrified residents fleeing for cover. Shells also struck a hospital, five high-rise apartment buildings and a building housing media outlets in Gaza City, injuring several journalists.

Bullets also entered another building housing The Associated Press offices, entering a room where two staffers were working but wounding no one. The Foreign Press Association, representing journalists covering Israel and the Palestinian territories, demanded a halt to attacks on press buildings.

The army had collected the locations of media organizations at the outset of fighting to avoid such attacks.

Israel launched its war on Dec. 27 in an effort to stop militant rocket fire from Gaza that has terrorized hundreds of thousands of Israelis. Some 1,100 Palestinians have been killed, roughly half of them civilians, according to U.N. and Palestinian medical officials. Gaza health official Dr. Moaiya Hassanain said at least 50 people were killed throughout Gaza on Thursday.

Thirteen Israelis also have been killed since the campaign began. Israel says it will press ahead until Hamas halts the rocket fire and stops smuggling weapons into Gaza from neighboring Egypt.

Israeli police said 20 rockets hit southern Israel on Thursday, injuring 10 people. Five of the wounded were in a car that was struck in the city of Beersheba.

The U.N. compound struck Thursday houses the U.N. Works and Relief Agency, which distributes food aid to hundreds of thousands of destitute Gazans in the tiny seaside territory of 1.4 million people.

“I conveyed my strong protest and outrage to the defense minister and foreign minister and demanded a full explanation,” said Ban, who arrived in Israel on Thursday morning from Egypt.

It had only that morning become a makeshift shelter for 700 Gaza City residents seeking sanctuary from relentless Israeli shelling, U.N. officials in Gaza said.

John Ging, director of UNRWA operations in Gaza, said the attack at the compound caused a “massive explosion” that wounded three people.

A senior Israeli military officer said troops opened fire after militants inside the compound shot anti-tank weapons and machine guns. The officer spoke on condition of anonymity pending a formal army announcement later in the day.

Ging, who was in the compound at the time, dismissed the Israeli account as “nonsense.”

Israeli shells first hit the courtyard filled with refugees, then struck garages and the U.N.’s main warehouse, sending thousands of tons of food aid up in flames, Ging said. Later, fuel supplies went up in flames, sending a thick black plume of smoke into the air.

“It’s a total disaster for us,” Ging said, adding that the U.N. had warned the Israeli military that the compound was in peril from shelling that had begun overnight. U.N. officials say they have provided Israel with GPS coordinates of all U.N. installations in Gaza to prevent such attacks.

The refugees were moved to a school away from the immediate fighting, he said.

Separately, Israel shells landed next to a U.N. school in another Gaza City neighborhood, wounding 14 people who had sought sanctuary there, medics and firefighters said.

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